Beyond the attacks, aides say the former vice president agonizes over how his hyper-public position has added to the formidable burdens of being his remaining son. If Hunter sounds down on the phone, Biden aides say, it can send his father into a funk and inflict a melancholy that lingers.

Mr. Biden will rarely bring up Hunter himself, they say, although others certainly will. When a reporter asks a skeptical question about Hunter, the mood in the room shifts. Aides become tense knowing that Mr. Biden might lash out. “You’re a damn liar, man,” Mr. Biden said, jarringly, at a December…



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